A Comparative Study of Pathology and Host Immune Response Induced by Very Virulent Infectious Bursal Disease Virus in Experimentally Infected Chickens of Aseel and White Leghorn Breeds

Characterization of a Highly Virulent Infectious Bursal Disease Virus

Very Virulent Infectious Bursal Disease Virus

The primary feature of vvIBDV is the ability to induce high mortality. Mortality ranges from 5% – 25% in broilers and 30% – 70% in layers. Surviving birds are severely affected with a high condemnation rate. vvIBDV induces clinical signs similar to Gumboro disease, which is induced by classical virulent strains of IBDV, except that the disease is more pronounced and acute in individual birds an...

Sequence analysis of the VP1 gene in three very virulent Iranian infectious bursal disease virus strains

Infectious bursal disease (IBD) is a highly contagious disease of chickens caused by the infectious bursal disease virus (IBDV). This study was conducted to characterize three IBDV strains from Iran. A reverse transcriptase-polymerase chain reaction (RT-PCR) procedure was used to amplify a 715-bp fragment of the VP1 gene from IBDV strains. Amplified VP1 fragments of the three Iranian IBDV strai...

Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease virus

BACKGROUND Very virulent infectious bursal disease virus (vvIBDV) induces immunosuppression and inflammation in young birds, which subsequently leads to high mortality. In addition, infectious bursal disease (IBD) is one of the leading causes of vaccine failure on farms. Therefore, understanding the immunopathogenesis of IBDV in both the spleen and the bursae could help effective vaccine develo...

Evaluation of Experimental Inactivated Infectious Bursal Disease Vaccine Using a Local Very Virulent Pathotype Strain